Winger Sofiane Boufal continues to recover from stubbing his big toe on the kitchen table at home, which has seen him restricted to substitute appearances.
Defender Yan Valery has been laid low following a viral infection, so will need more time to regain full fitness.
West Ham should have Aaron Cresswell fit for this weekend's crucial clash at St Mary's.
The left-back limped off during Monday's 3-1 defeat to Arsenal, but returned to training ahead of the clash with the Saints.
Provisional Southampton squad: McCarthy, Soares, Stephens, Bertrand, Bednarek, Djenepo, Ward-Prowse, Redmond, Hojbjerg, Long, Ings, Gunn, Yoshida, Vestergaard, Romeu, Boufal, Adams, Obafemi
Provisional West Ham squad: Martin, Fredericks, Ogbonna, Balbuena, Cresswell, Rice, Noble, Snodgrass, Anderson, Fornals, Antonio, Roberto, Zabaleta, Diop, Masuaku, Sanchez, Yarmolenko, Holland, Haller, Ajeti.