Southampton manager Mauricio Pochettino has handed home debuts to new signings Victor Wanyama and Dejan Lovren.
Wanyama has been brought in from Celtic, while Lovren has moved to England from Lyon, and both will make their first appearance at the St Mary's Stadium.
Rickie Lambert, who was called up by England earlier this week, will partner Jay Rodriguez in attack.
Pochettino has also selected 18-year-old full-back Calum Chambers.
Southampton: Boruc, Chambers, Lovren, Hooiveld, Shaw, Wanyama, Schneiderlin, Lallana, Guly, Rodriguez, Lambert
Real Sociedad: Bravo, Sangalli Ansotegi, Cadamuro, De la Bella, X.Prieto, Elustondo, Ros, Sailing, Seferovic, Chory