La Roja's preparations for this summer's competition have been difficult, with Busquets and then Diego Llorente testing positive for coronavirus, but the latter has now recorded two negative tests.
There are a number of unknowns when it comes to team selection, with relatively few of the current squad actually guaranteed positions in the first XI.
Alvaro Morata is the leading goalscorer in the squad with 19 - 11 more than anyone else - and the 28-year-old should be given the nod at centre-forward, with the likes of Adama Traore, Mikel Oyarzabal, Pablo Sarabia and Dani Olmo set to start on the bench.
Spain possible starting lineup: Simon; M Llorente, Laporte, P Torres, Alba; Thiago, Rodri, Koke; F Torres, Morata, G Moreno
> Click here to see how Sweden could line up for the clash body check tags ::