Spain's plans for Euro 2020 have been thrown into disarray, with Sergio Busquets testing positive for coronavirus, meaning that the senior squad cannot take part in Tuesday's friendly with Lithuania.
Indeed, as a result of players being forced to self-isolate, members of Spain Under-21s will be called upon for this match, while the team will be led by Under-21 manager Luis De la Fuente.
The XI is expected to have a similar look to the one that took to the field for the Under-21 European Championship semi-final against Portugal on Thursday evening.
There should still be a number of recognisable names in the side, with Brahim Diaz, Bryan Gil, Oscar Mingueza and Marc Cucurella set to be included in the starting XI.
Abel Ruiz, Fran Beltran and Yeremi Pino should also play a part for the home side, while Javi Puado, who plays his club football for Espanyol, could lead the line for La Roja.
Originally, Aymeric Laporte looked to be in line to win his second cap in the middle of the defence, but Barcelona's Mingueza could now be joined by Jorge Cuenca at the back.
Spain possible starting lineup: Fernandez; Oscar, Mingueza, Cuenca, Cucurella; Zubimendi, Villar; Diaz, Garcia, Gil; Puado