The La Liga giants, seeking a third successive triumph in the Champions League this season, possess a number of world-class players in their ranks.
While the talents of Cristiano Ronaldo are well known, though, Pochettino admits that he is particularly wary of Spain international Isco, who has blossomed into a key player for Madrid since Zinedine Zidane took charge.
"I think that he is one of the best and he is proving it," he told reporters. "I have been lucky to have seen him playing for different clubs and he has always been a player with a capacity and creativity above average.
"He has reached his full potential at Real, and we will take that into account. We know all about his magic."
Isco has two goals and two assists in 10 appearances for Madrid in all competitions this season.