Nabil Bentaleb will miss Tottenham Hotspur's Europa League Group C tie with Asteras Tripolis on Thursday evening with an ankle problem.
The Algerian midfielder picked up the injury on international duty and was not named in the Spurs squad for their 4-1 defeat to Manchester City on Saturday.
The 19-year-old joins Kyle Walker and Kyle Naughton on the sidelines, with both right-backs also unavailable for the visit of the Greeks as they recover from abdominal and ankle issues respectively.
Spurs boss Mauricio Pochettino is expected to make as many as 10 changes for the match at White Hart Lane, with Mousa Dembele and Benjamin Stambouli poised for starts in midfield in the absence of Bentaleb.
Tottenham have drawn their two Group C games, while Tripolis are top of the standings with four points.