Tottenham Hotspur attacker Dejan Kulusevski will not recover from a hamstring problem in time for Saturday's Premier League clash with Everton.
The Swede was back in partial training prior to Wednesday's Champions League win over Eintracht Frankfurt, but Antonio Conte does not believe that it is worth risking him for the weekend.
Defender Japhet Tanganga also remains a slight doubt with a knock, while Emerson Royal is set to serve the second of a three-game ban after his North London derby red card.
Tanganga would have had little chance of displacing Cristian Romero or Eric Dier anyway, but Ben Davies is in with a strong chance of coming back in for Clement Lenglet in front of Hugo Lloris.
Matt Doherty was given the nod in Emerson's absence against Brighton & Hove Albion and should start again here, while Ryan Sessegnon could make way for the fresh legs of Ivan Perisic on the opposite side.
Pierre-Emile Hojbjerg and Rodrigo Bentancur should form a two-man midfield, with Conte likely to move away from the 3-5-2 given his attacking returns, one of which saw Lucas Moura come on for the final 10 minutes on Wednesday.
With Kulusevski still building up his fitness and also a doubt for next week's clash with Manchester United, Harry Kane and Son Heung-min should be joined by Richarlison, who goes in search of his first Premier League goal for Tottenham against his former club.
Tottenham possible starting lineup: Lloris; Romero, Dier, Davies; Doherty, Hojbjerg, Bentancur, Perisic; Richarlison, Kane, Son
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