Roberto Martinez has made one change to the Everton team that beat Aston Villa 2-0 last weekend, with Leon Osman replacing Ross Barkley, who drops to the bench.
Meanwhile, Tottenham Hotspur boss Andre Villas-Boas has rung the changes from the side that progressed on penalties in Wednesday's League Cup tie with Hull City, with eight new faces in the starting lineup.
The only survivors are Kyle Walker, Paulinho and Jan Vertonghen.
Everton: Howard; Coleman, Jagielka, Distin, Baines; McCarthy, Barry, Osman, Pienaar, Mirallas; Lukaku
Tottenham Hotspur: Lloris; Walker, Chiriches, Dawson, Vertonghen; Paulinho, Sandro; Lennon, Holtby, Townsend; Soldado
You can follow Sports Mole's live minute-by-minute commentary of today's game at Goodison Park here.