Lamela has been absent since he was pictured breaking coronavirus rules over the festive period, with Mourinho hinting at a period of self-isolation.
Fulham manager Scott Parker said none of his players were feeling any after-effects of Covid-19 after admitting the club had "had it tough" in terms of the virus.
Parker made a number of changes for his side's FA Cup third-round win at QPR on the weekend, with Alphonse Areola, Ademola Lookman, Tom Cairney, Joachim Andersen and Frank Anguissa among the absentees, and it remains to be seen how many will be available against Spurs.
Tottenham provisional squad: Lloris, Hart, Gazzaniga, Tanganga, Aurier, Alderweireld, Dier, Sanchez, Davies, Reguilon, Winks, Hojbjerg, Sissoko, Fernandes, Ndombele, Moura, Vinicius, Alli, Lamela, Bergwijn, Son, Kane.
Fulham provisional squad: Areola, Aina, Adarabioyo, Andersen, Robinson, Reed, Lookman, Loftus-Cheek, Decordova-Reid, Cavaleiro, Mitrovic, Rodak, Ream, Kongolo, Kebano, Onomah, Tete, Cairney, Bryan, Kamara