In games which came within 65 hours of each other, Spurs succumbed to narrow defeats to RB Leipzig and Chelsea respectively.
However, while Wolves have played twice since Spurs lost out at Stamford Bridge, the North Londoners will have enjoyed an eight-day break come kickoff this weekend.
Here, Sports Mole predicts how Jose Mourinho's side could line up for the Premier League contest in England's capital.
Having talked up Erik Lamela after his last two substitute outings, it would come as a surprise if Mourinho did not hand a recall to the Argentine for this game.
Dele Alli should also feature in the first XI, potentially in the number 10 role if Mourinho decides to revert to a 4-2-3-1 formation.
After lasting just over an hour against Chelsea, Tanguy Ndombele will likely be the player to drop down to the bench.
Ryan Sessegnon has joined Spurs' injury list after sustaining a hip injury.