Tottenham Hotspur manager Antonio Conte will be forced into a pair of defensive changes for Saturday's Premier League clash with Leicester City at the King Power Stadium.
The Lilywhites will likely welcome the Italian back to the dugout this weekend after his gallbladder removal, but they have lost captain and first-choice goalkeeper Hugo Lloris for between six and eight weeks due to a knee injury.
Lloris sustained the issue towards the end of Sunday's 1-0 win over Manchester City, where Cristian Romero was also sent off late on for two bookable offences.
Romero will therefore serve a one-game ban at the King Power, while Pape Sarr (hip) and Lucas Moura (tendon) will both need assessing, and Yves Bissouma is out following ankle surgery.
Fraser Forster will have some big gloves to fill as he deputises for Lloris in goal, while either Davinson Sanchez or Clement Lenglet will step in for the suspended Romero at the back.
Sanchez came on for the final few moments against Man City and will likely be given the nod by Conte to join Eric Dier and Ben Davies, with Lenglet traditionally playing on the left-hand side.
Pedro Porro's wait for a first appearance may continue after Emerson Royal put in another dogged performance against Man City, while Pierre-Emile Hojbjerg, Rodrigo Bentancur and Ivan Perisic should all retain their spots.
Harry Kane's winner against Man City saw the 29-year-old become Tottenham's all-time highest scorer of all time with 267 strikes - 18 of which have come against Leicester in the Premier League.
Lining up from the off against his former club and favourite opponent, Kane can expect to receive support from Dejan Kulusevski and Son Heung-min, who scored a 13-minute hat-trick in this fixture in September.
Tottenham Hotspur possible starting lineup: Forster; Sanchez, Dier, Davies; Emerson, Hojbjerg, Bentancur, Perisic; Kulusevski, Kane, Son