Etienne Ndayiragije's men saw off Namibia 1-0 last time out, while the Syli Nationale were held to a 1-1 draw by Zambia.
The Taifa Stars secured their spot in the tournament in dramatic style, edging out Sudan on penalties after their two-legged tie finished 2-2 on aggregate.
This is just Tanzania's second appearance in the competition, after failing to qualify since the 2009 edition, where they were eliminated at the group stages.
They ended an eight-game winless run in all competitions over the weekend thanks to Faridi Mussa's second-half strike, which will have filled them with confidence coming into this one.
Three points would guarantee their progression to the quarter-finals and give the East African nation genuine hope that they can go all the way to the showpiece event.
Guinea are top of Group D after picking up four points from their opening two games of the tournament.
Kanfory Mohamed Bangoura is in his second stint in charge of the West Africans, and he will be hoping his side can pick up the point they require to progress to the knockout stages in midweek.
Bangoura's men were denied back-to-back wins by an 87th-minute strike from Zambia's Spencer Sautu last time out, meaning only one point separates the top three teams in the group.
Guinea's best result in the competition came back in 2016 when they finished in fourth place. A repeat performance would be considered a huge success and one that the group leaders will have set their sights on.
Tanzania African Nations Championship form: LW
Tanzania form (all competitions): LLDDLW
Guinea African Nations Championship form: WD
Guinea form (all competitions): WWDLWD
Twenty-two-year-old winger Ayubu Lyanga is the only guaranteed absentee for Tanzania, after the Azam FC forward picked up an injury in the opening game of the championships.
Their impressive victory over the weekend means Ndayiragije is likely to stick with the same starting XI that defeated Namibia, meaning Ditram Nchimbi is set to lead the line once again.
Star striker Yakhouba Gnagna Barry bagged two goals in the opening day victory over Namibia, and his nation will once again be looking to him to provide the attacking intent.
Ismael Camara has made two appearances from the bench so far, providing one assist in his short time on the pitch, and he will be pushing for his first start in this upcoming encounter.
Tanzania possible starting lineup:
Manula; Kapombe, Mwamnyeto, Protus, Manyama; Majogoro; Mhilu, Salum, Kikoti, Adam; Nchimbi
Guinea possible starting lineup:
Camara; Camara, Doumbouya, Traore, Bangoura; Camara, Sylla, Kante, Coumbassa; Bangoura, Barry
We say: Tanzania 1-2 Guinea
It should be a close, tight affair between two evenly matched teams fighting for their place in the competition. We fancy Guinea to seal the victory, though, and progress to the quarter-finals given the extra quality in Bangoura's squad.
Top betting tip
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