The Hammers have lost their opening two league games of the campaign, while Wolves have a mixed return of one win and one defeat so far.
Two games into the Premier League season and David Moyes is already the clear favourite to be the first manager sacked on the back of United's slow start.
Moyes's men followed up a 2-0 loss at home to Newcastle United on the opening weekend with a late 2-1 defeat against Arsenal and have a tough run of fixtures to come.
Indeed, the meeting with Arsenal was the first of six in a row against last season's top eight, culminating in a trip to champions Liverpool on Halloween weekend.
Taking time to get going is nothing new for the Irons, though, having lost two of their opening three matches in two of the last three seasons.
United, who did manage to brush aside Hull City in the EFL Cup third round in midweek, must also cope without their manager in the dugout this weekend.
The Scotsman tested positive for coronavirus hours before kickoff against Hull in a farcical situation and must now self-isolate, meaning that Alan Irvine will take charge.
This is not a fixture United tend to do well in, either, losing their last four league encounters with Wolves without scoring a single goal.
Unlike their opponents, Nuno Espirito Santo's charges have had a full week's rest, too, after being eliminated from the EFL Cup in the second round.
Nuno will know that there are areas to improve on following the 3-1 loss to Manchester City last time out, with Wolves deservedly beaten after taking too long to get going.
Wanderers do have some points on the board, however, thanks to a 2-0 victory against Sheffield United on the opening weekend, and have a nice set of fixtures ahead.
That includes this trip to the London Stadium, where West Ham have failed to keep a clean sheet in their last 10 matches - their longest such run in more than a decade.
West Ham United Premier League form: LL
West Ham United form (all competitions): LWLW
Wolverhampton Wanderers Premier League form: WL
Wolverhampton Wanderers form (all competitions): WLL
However, it is more likely that Michail Antonio, who has scored 60% of United's league goals in 2020, will lead the line once again.
As for the visitors, eyebrows were raised after they splashed out a massive £37m to sign Nelson Semedo from Barcelona in the week.
Up top, Jimenez has scored three goals in his last three Premier League games against West Ham, including the opening goal in his side's 2-0 win at the London Stadium last season.
West Ham United possible starting lineup:
Fabianski; Fredericks, Balbuena, Ogbonna, Cresswell, Masuaku; Bowen, Rice, Soucek, Fornals; Antonio
Wolverhampton Wanderers possible starting lineup:
Patricio; Boly, Coady, Saiss; Semedo, Neves, Moutinho, Vinagre; Traore, Jimenez, Podence
We say: West Ham United 1-3 Wolverhampton Wanderers
West Ham picked up a morale-boosting victory in the EFL Cup in midweek and will be desperate to carry that into the Premier League.
Without their manager in the dugout, however, and with Wolves fully rested, we are expecting the Irons' home struggles to continue.
Top betting tipOur expert tipster partners at Sporita.com are predicting over 1.5 goals in this match. Click here to find out what else they are predicting for this game and for more of their tried-and-tested football tips.Over 1.5:data
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