Wigan Athletic, Ipswich Town, Bolton Wanderers and Charlton Athletic were just some of the sides on the receiving end of giant-killings in the first round of the League Cup.
Latics defender Jake Buxton saw red at Boundary Park as goals from Ryan Flynn and Josh Law gave Oldham Athletic a 2-1 win, while Ipswich fell to a solitary Ben Kennedy strike as Stevenage clinched a 1-0 win at Portman Road.
Fallen giants Charlton suffered a 1-0 loss at Cheltenham Town, courtesy of a first-half Harry Pell strike, while Bolton succumbed to a 4-2 defeat at the hands of Blackpool at the Macron Stadium.
Other sides that suffered shock first-round exits on Tuesday night include Rotherham United, victims of a 5-4 loss to Morecambe, and Sheffield Wednesday, undone 2-1 by Cambridge United.
Teams that successfully negotiated opponents beneath them in the pyramid include Fulham, who withstood a late Paul McCallum-inspired fightback to beat Leyton Orient 3-2; Blackburn Rovers, comfortable 3-1 winners at Mansfield Town; and Nottingham Forest, who were helped out by an injury-time Jamie Ward strike to defeat Doncaster Rovers 2-1 at the Keepmoat Stadium.
League Cup first round results in full: Barnsley 1-2 Northampton, Birmingham 0-1 Oxford Utd, Blackpool 4-2 Bolton, Brighton 4-0 Colchester, Cambridge 2-1 Sheff Weds, Carlisle 2-1 Port Vale, Cheltenham 1-0 Charlton, Coventry 3-2 Portsmouth, Derby 1-0 Grimsby Town, Doncaster 1-2 Nott'm Forest, Exeter 1-0 Brentford, Ipswich 0-1 Stevenage, Leyton Orient 2-3 Fulham, Mansfield 1-3 Blackburn, Newport County 2-3 MK Dons, Oldham 2-1 Wigan, Peterborough 3-2 AFC Wimbledon, Preston 1-0 Hartlepool, Rochdale 3-1 Chesterfield, Rotherham 4-5 Morecambe, Scunthorpe 2-0 Notts County, Sheff Utd 1-2 Crewe Alexandra, Shrewsbury 2-1 Huddersfield, Southend 1-3 Gillingham, Walsall 0-2 Yeovil, Wolves 2-1 Crawley, Wycombe 0-1 Bristol City, Barnet 0-4 Millwall, Reading 2-0 Plymouth, Accrington 0-0 Bradford (Accrington win 11-10 on penalties)