Mark Robins has handed a debut to summer signing Jamie Ness for tonight's visit to Wigan Athletic in League One.
The midfielder, 24, joined on a Bosman after being released by Stoke City, and he is one of two changes by Robins from the 2-0 win over Crewe Alexandra.
Captain Stephen Dawson also returns as the duo replace Sean McAllister and Gary McSheffrey respectively.
Likewise, Latics boss Gary Caldwell also makes two changes from the 0-0 draw with Doncaster Rovers last time out, with Craig Davies and Donervon Daniels coming in.
Will Grigg leads the hosts' forward line as he chases a first Wigan goal following his summer move from Brentford.
Wigan Athletic: O'Donnell; James, Perkins, Daniels, Morgan; McCann, Jacobs, Kenny, Francisco; Grigg, Davies
Scunthorpe United: Anyon; Wiseman, Clarke, Mirfin, King; Laird, Ness, Bishop, Dawson; Hopper, Madden
