Australia's stand-in captain for the Rugby Championship Will Genia is expected to be sidelined for six months with a knee injury.
Scans show that Genia has ruptured his anterior cruciate ligament.
Wallabies coach Robbie Deans said: "Will Genia is not there and Will Genia is a special player, there's no doubt. But as we've seen in recent times it's a team game and no-one can do it by themselves and the group that combines effectively is more dangerous than one man.''
Australia are already without captains James Horwill and David Pocock.