England centre Henry Slade has been ruled out of next year's Six Nations after breaking his leg while playing for Exeter Chiefs.
The 22-year-old suffered the injury during Saturday's 41-27 Aviva Premiership victory over Wasps.
He underwent surgery on Sunday and Exeter are yet to set a date for his return.
"We are certainly not pencilling in any date for Henry's return because we know it is long-term," Chiefs head coach Rob Baxter told the club website.
"We will start talking about a return date in eight to 10 weeks' time when we know a bit more - it will take a bit of time though and a lengthy rehab process."
Baxter also confirmed that flanker Dave Ewers will not feature again before the New Year because of knee ligament trouble.
