Christian Wade and Matt Kvesic will make their full England debuts when Stuart Lancaster's men face Argentina in Saturday's first Test.
Meanwhile, former rugby league star Kyle Eastmond will make his first cap as a replacement, as will Henry Thomas and Billy Vunipola.
Freddie Burns, Rob Webber and Dave Attwood, who have previously made cameos off the bench, are all in the starting XV.
Experienced centre Gonzalo Tiesi will feature for Argentina, who will be captained by Felipe Contepomi.
England XV: Mike Brown, Christian Wade, Jonathan Joseph, Billy Twelvetrees, David Strettle, Freddie Burns, Lee Dickson, Ben Morgan, Matt Kvesic, Tom Wood (c), Dave Attwood, Joe Launchbury, David Wilson, Rob Webber, Joe Marler
Replacements: Mauricio Guidone, Guillermo Roan, Francisco Gomez Kodela, Tomas Vallejos, Tomas De la Vega, Nicolas Vergallo, Gabriel Ascarate, Belisario Agulla
Argentina XV: Martin Bustos Moyano, Matias Orlando, Gonzalo Tiesi, Felipe Contepomi (c), Manuel Montero, Benjamin Urdapilleta, Martin Landajo, Tomas Leonardi, Benjamin Macome, Julio Farias Cabello, Mariano Galarza, Esteban Lozada, Maximiliano Bustos, Martin Garcia Veiga, Pablo Henn
Replacements: Mauricio Guidone, Guillermo Roan, Francisco Gomez Kodela, Tomas Vallejos, Tomas De la Vega, Nicolas Vergallo, Gabriel Ascarate, Belisario Agulla
