England will be without Wasps duo Matt Mullan and Elliot Daly for their training camp in Portugal next week due to injuries sustained against Northampton Saints.
Mullan damaged his elbow during the 38-22 victory at Franklin's Gardens on Saturday afternoon, while Daly had to leave the field with a knee problem.
Both players will now undergo scans to reveal the full extent of the injuries, ruling them out of Eddie Jones's group for the Portugal camp at the very least.
England, who have not called up any replacements, face Argentina at Twickenham on November 11 in the first of their Autumn Internationals.
Australia and Samoa also travel to Twickenham on November 18 and November 25 respectively.