Head coach Stuart Lancaster has said that he will select England's strongest possible lineup for their Rugby World Cup opener against Fiji.
England will play Fiji at Twickenham on Friday before matches against Wales, Australia and Uruguay.
"I think we've got to pick our strongest team to start with," Lancaster told Sky Sports News.
"We obviously trust the guys in the squad, so sometimes you might freshen the team up by changing a Joe Launchbury for Courtney Lawes, Ben Morgan and Billy Vunipola, Danny Care.
"There's all sorts of changes we could make, but not wholesale changes. There are bound to be injuries. I don't think any team has gone throughout a tournament without one of those. I think in 2011 there were only three players who played in all seven games."
England completed their preparations for the tournament with a 21-13 victory over Ireland last week.