England have sprung a surprise by naming Northampton debutant George Furbank at full-back for Sunday's Guinness Six Nations opener against France in Paris.
Furbank has been thrust into the starting XV as part of a reshuffled back three after Anthony Watson withdrew from contention on Thursday because of a calf injury.
The 23-year-old has been highly influential in Saints' superb start to the Gallagher Premiership with his speed, running lines and vision catching the eye of Eddie Jones.
Mako Vunipola is missing from the matchday 23 completely despite England stating on Wednesday that he was forced to miss that day's training session with an eye injury as a precautionary measure only.
Joe Marler starts at loosehead prop in his absence as one of three changes in personnel to the side toppled 32-12 by the Springboks in Yokohama last autumn.
Charlie Ewels comes into the second row and Courtney Lawes moves to blindside flanker with Tom Curry replacing broken-arm victim Billy Vunipola at number eight.
Bath prop Will Stuart is set to be the second uncapped player to make his debut at the Stade de France after being picked on the bench.
"It has been a massively exciting week for us," said Jones, whose squad have been preparing for the Six Nations in the Algarve.
"It's the start of the Six Nations, the best rugby tournament in the world. We have had a great preparation in Portugal with a quality training week this week.
"France can expect absolute brutality from England, we are going to go out there to make sure they understand what Test rugby is.
"It is about being brutal, it is about being physical and it is about dominating the set piece."
