Italy have made six changes to their team for Saturday's Six Nations clash against England at Twickenham.

Jacques Brunel has introduced Mauro Bergamasco and Marco Bortolami into the side at blindside flanker and lock respectively, in place of Alessandro Zanni and Joshua Furno.

Andrea Masi will start alongside Luca Morisi due to the absence of Michele Campagnaro, who is currently nursing an injury, while Giovambattista Venditti and Luke McLean have also been given the nod.

Matias Aguero has been replaced with Albert de Marchi at loosehead prop for Italy, who suffered a 26-3 defeat to Ireland in last weekend's opener.

Italy team to face England: Luke McLean, Leonardo Sarto, Luca Morisi, Andrea Masi, Giovambattista Venditti, Kelly Haimona, Edoardo Gori, Sergio Parisse, Francesco Minto, Mauro Bergamasco, Marco Bortolami, George Fabio Biagi, Martin Castrogiovanni, Leonardo Ghiraldini, Alberto de Marchi

Replacements: Andrea Manici, Matias Aguero, Dario Chistolini, Joshua Furno, Samuela Vunisa, Guglielmo Palazzani, Tommaso Allan, Giulio Bisegni