Wales captain Sam Warburton and Justin Tipuric will pair up for their Rugby World Cup opener against Uruguay on Sunday.
The new-look back row incorporates the duo, while James King will start at number eight at the Millennium Stadium.
Head coach Warren Gatland has welcomed back Liam Williams and Samson Lee following the pair's spell on the sidelines with injury, with the former partnering Alex Cuthbert and Hallam Amos in a back three.
Cory Allen and Scott Williams have been included in midfield, while Rhys Priestland and Gareth Davies will team up for the opening contest.
Lee, Paul James and Scott Baldwin make up the front row, with Jake Ball and Luke Charteris in the second row.
Wales team to play Uruguay: Liam Williams (Scarlets), Alex Cuthbert (Cardiff Blues), Cory Allen (Cardiff Blues), Scott Williams (Scarlets), Hallam Amos (Newport Gwent Dragons), Rhys Priestland (Bath Rugby), Gareth Davies (Scarlets); Paul James (Ospreys), Scott Baldwin (Ospreys), Samson Lee (Scarlets), Jake Ball (Scarlets), Luke Charteris (Racing 92), Sam Warburton (Captain, Cardiff Blues), Justin Tipuric (Ospreys), James King (Ospreys).
Replacements: Ken Owens (Scarlets), Aaron Jarvis (Ospreys), Tomas Francis (Exeter Chiefs), Dominic Day (Bath Rugby), Dan Lydiate (Ospreys), Ross Moriarty (Gloucester Rugby), Lloyd Williams (Cardiff Blues), Matthew Morgan (Bristol Rugby)
