Nemanja Vidic has recovered from injury and takes his place in the centre of defence alongside Jonny Evans for today's match against Fulham.
Javier Hernandez drops out for the visitors despite three goals in two games, which means that Wayne Rooney and Robin van Persie lead the line.
Michael Carrick also drops out, allowing Phil Jones to move into midfield.
Darren Bent is only on the bench for Fulham, but Dimitar Berbatov does start against his former team.
Ashkan Dejagah also plays, as does Kieran Richardson.
Fulham: Stekelenburg; Riether, Senderos, Amorebieta, Richardson; Dejagah, Sidwell, Parker, Kasami; Ruiz; Berbatov
Manchester United: De Gea; Rafael, Vidic, Evans, Evra; Valencia, Jones, Cleverley, Janzuaj; Rooney, Van Persie
