Sampdoria vs. Atalanta (Sunday, 11.30am)
The fifth-placed Orobici are seeking to secure European football again next season, while Claudio Ranieri's Samp sit comfortably in mid-table, despite their loss to Lazio last week.
We say: Sampdoria 1-3 Atalanta BC
The vengeful visitors can reverse the result they surprisingly suffered in the previous meeting between these two clubs, using their sense of grievance about Champions League refereeing standards as fuel for their fire.
Though Sampdoria are capable of springing an upset every now and then, they could be over-powered by Atalanta's blistering attack if the boys from Bergamo click straight back into gear.
Crotone vs. Cagliari (Sunday, 2.00pm)
The visitors head into this clash without a league win in over three months and with a new head coach at the helm, while Crotone are hoping to avoid losing six successive top-flight matches for the first time in their history.
We say: Crotone 1-1 Cagliari
In the quest for Serie A salvation, both sides know how important claiming three points would be and hope that a positive result this weekend can provide a springboard for the rest of their respective campaigns.
Cagliari will fancy their chances of scoring their first league goal this month against a Crotone outfit that are conceding on average around 2.5 goals per game in the top-flight this season.
However, with little to separate the two out-of-form teams, a draw could be on the cards – a result that neither side would really benefit from.
Udinese vs. Fiorentina (Sunday, 2.00pm)
The visitors are looking to win only their second top-flight match on the road and claim successive league victories for the first time this season, while Udinese, who have not beaten La Viola since April 2016, could go four home games unbeaten if they avoid defeat this weekend.
We say: Udinese 1-1 Fiorentina
A win for either side on Sunday would most likely keep them away from any potential relegation battle this campaign and draw their attention to the top half instead of the bottom three.
Fiorentina's abysmal away form is halting their progress in Serie A but facing an Udinese outfit that they have impressed against in recent seasons could breed confidence into Prandelli's side.
The hosts, however, have improved their own form of late which could see a tight encounter this weekend, with a draw a likely result at the Stadio Friuli.
Inter Milan vs. Genoa (Sunday, 2.00pm)
The previously troubled Grifone travel to San Siro unbeaten in seven, while their hosts have only lost once in the league since October.
We say: Inter Milan 2-0 Genoa
Inter were impressively calculating in the Derby, demonstrating all of the characteristics required to become champions, and are set to continue keeping the pace high in the title race.
The Nerazzurri can post a fourth win in a row (and a ninth straight home success) despite Genoa's vast improvement of late. As the two sides match up similarly in terms of formation, the hosts' far greater individual quality - plus high-calibre options on the bench - will prove the deciding factors.
Napoli vs. Benevento (Sunday, 5.00pm)
After suffering double disappointment in the past week, inconsistent Napoli welcome their Campanian counterparts Benevento to Stadio Diego Maradona on Sunday, intent on making up lost ground on Serie A's top four.
Meanwhile, the visitors continue to defy expectations this season, with their latest positive performance resulting in a gritty draw against high-flying Roma last time out.
We say: Napoli 3-1 Benevento
Napoli's recent home form is particularly strong and Benevento's best performances have tended to come on the road.
With both sides enduring rocky starts to 2021 though, their greater individual quality and more pressing need for points should see the hosts take advantage of their local rivals' flaws at both ends.
A repeat of last autumn's result at the Vigorito is to be expected, with the Azzurri's domination over their neighbours extending to four wins out of four.
Roma vs. AC Milan (Sunday, 7.45pm)
Still unbeaten at home, fourth-placed Roma look to close to within two points of their Scudetto-chasing visitors AC Milan on Sunday, as two giants of Calcio clash in the capital.
Both sides secured progress to the last-32 of the Europa League in midweek - in very different fashion - after enduring lamentable league results at the weekend.
We say: Roma 1-1 AC Milan
Despite Milan's points advantage and status as 'winter champions', these two teams are quite equally matched, as Roma's attacking threat - particularly on home soil - is often enough to sink all-comers and the Rossoneri have descended from the crest of a months-long wave.
Nonetheless, the Giallorossi certainly suffer from a deficit in belief and composure when facing the top sides, so may be frustrated again - with a draw playing straight into the hands of both Inter and Juventus in the fight for the title.