While the home side have been inconsistent of late, getting the better of the league leaders will keep them in the hunt for the top-flight crown.
Having progressed through to the last 16 of the Europa League, there will come a time when Erik ten Hag will place more focus on trying to end Ajax's wait for a European trophy.
However, there is still work to do on the domestic scene, especially this weekend as Ajax look to record a victory which will realistically leave them having one hand on the top-flight crown.
Dropping just four points in 11 league matches has led to the defending champions extending their advantage over their next opponents, who have also played a game more than their rivals.
Sebastien Haller has been left frustrated due to being accidentally omitted from the club's European fixtures, but already contributing five goals and five assists in eight matches suggests that his extra freshness will prove key in the long term.
On the same night that Ajax were able to edge past Lille, PSV were dumped out of the Europa League after losing 5-4 on aggregate to Olympiacos.
Roger Schmidt's side were on their way through to the last 16 on away goals until Koka scored with two minutes remaining, delivering a hammer blow to a team which have under-performed in recent weeks.
Now out of both cup competitions, Schmidt and his side are left to focus on the Eredivisie, knowing that anything other than a win on Sunday may leave them with too much ground to make up during the final third of the season.
Schmidt will take the positives from wins being recorded against Vitesse and Olympiacos over 90 minutes, but his defence have now kept just one clean sheet in seven matches.
PSV Eindhoven Eredivisie form: WWLWDW
PSV Eindhoven form (all competitions): WLDLWW
Ajax Eredivisie form: WWWWWW
Ajax form (all competitions): WWWWWW
Schmidt will again be without Ibrahim Sangare, who follows his European suspension with a one-match ban in the Dutch top flight.
Haller will return to the Ajax XI after sitting out the victory over Lille earlier this week.
PSV Eindhoven possible starting lineup:
Mvogo; Dumfries, Teze, Viergever, Max; Boscagli, Rosario; Thomas, Zahavi, Gotze; Malen
Ajax possible starting lineup:
Stekelenburg; Rensch, Timber, Martinez, Blind; Alvarez, Gravenberch; Antony, Klaassen, Tadic; Haller
We say: PSV Eindhoven 1-2 Ajax
After their efforts in midweek, tiredness will inevitably be a factor. Ajax's greater strength in depth could end up proving decisive, leading us to predict that the visitors will outlast their rivals in the closing stages to claim maximum points.