The hosts beat Bahia 4-3 last time out to make it three games without defeat, while Santos enter this match unbeaten in four.
Santos may have lost just one of their last seven league games, but they have been held in two of their last four outings, including a goalless draw with Sport Recife in midweek.
The Black-and-White dominated the match in terms of possession and shots, yet they could only find the target from one of their 14 efforts.
Fernando Diniz's side have now failed to score in exactly half of their eight league games this season, perhaps explaining why they are outside of the top six.
On their travels, meanwhile, Santos have taken one point from a possible nine this term, while going further back they are winless in eight since January.
America Mineiro are winless in their four home games since returning to the top flight, albeit the last three of those matches finishing all square.
After drawing 1-1 with Juventude and Internacional on home soil, the Rabbit beat Bahia in a seven-goal classic last time out to move out of the relegation zone.
Vagner Mancini's charges did make life rather tough for themselves, however, as they led 4-1 in that game before conceding two goals in added time at the end of the contest.
Attention now switches to the visit of Santos, and what will be the first meeting between the sides since November 2018 when America prevailed 2-1 winners.
Given those injury issues, plus the manner of his side's performance against Bahia - for 90 minutes, at least - Mancini may elect to field the same XI here.
As for Santos, they will welcome Marinho back from suspension for this game, and he is expected to slot straight back into the forward line.
That could spell bad news for Lucas Braga, who is the most likely candidate to make way up top.
America Mineiro possible starting lineup:
Cavichioli; Eduardo, Bauermann, Anderson, Paulo; Juninho, Rodolfo, Ricardo; Toscano, Ribamar, Azevedo
Santos possible starting lineup:
Paulo; Para, Peres, Felipe, Jonatan; Pirani, Mota, Camacho; Marinho, Jorge; Guilherme
We say: America Mineiro 1-1 Santos
Santos are struggling for consistency, seemingly alternating between a win and a draw on a weekly basis.
America Mineiro are draw specialists at home, meanwhile, and we can see them taking a point off their opponents here.
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