Last season's Premier League runners-up host the reigning champions in Sunday's blockbuster Emirates battle, as Arsenal renew hostilities with Manchester City.
The Gunners are seeking to redeem themselves following a 2-1 loss to Lens in the Champions League, where goals from Elye Wahi and Adrien Thomasson cancelled out a Gabriel Jesus opener.
Despite falling short in Europe, Mikel Arteta's side remain undefeated domestically so far and are just one point adrift of the champions owing to their 4-0 drubbing of Bournemouth last weekend.
Here, Sports Mole rounds up Arsenal's injury and suspension news ahead of their headline encounter with Man City, who bested RB Leipzig 3-1 in the Champions League on Wednesday.
Status: Major doubt
Type of injury: Hamstring
Possible return date: October 8 (vs. Man City)
Ever since Gabriel Martinelli suffered a hamstring injury against Everton on September 17 - the severity of which has not been disclosed - Arteta has repeatedly refused to rule the Brazilian out of his side's next game, but it would be a surprise to see the South American passed fit to take on the Citizens.
Status: Major doubt
Type of injury: Hamstring
Possible return date: October 8 (vs. Man City)
Arteta's decision to risk Bukayo Saka from the start against Lens raised a few eyebrows due to the winger's recent knocks, and the Spaniard's move backfired when Saka left the field with a hamstring problem in the first half, but the Englishman is "in contention" to face Pep Guardiola's team.
Status: Out
Type of injury: Knee
Possible return date: Unknown
Jurrien Timber has been recovering from a serious ACL injury for the past two months, but it will still be a while before the Dutchman is seen in the red and white strip again.
ARSENAL'S SUSPENSION LIST
Arsenal have no players suspended for this match.