Wesley is out for the season with a knee injury, Keinan Davis has only just returned to training after nearly three months out with a hamstring problem, while Jonathan Kodjia has been sold to Qatari side Al Gharafa.
Ismaila Sarr has been ruled out of Watford's trip to Villa Park.
Sarr limped off with a hamstring injury in his side's goalless draw against Tottenham and faces a spell on the sidelines.
Danny Welbeck is closing in on a return but the game against Villa comes too soon for the former England international.
Aston Villa provisional squad: Reina, Nyland, Guilbert, Engels, Chester, Konsa, Mings, Taylor, Elmohamady, Luiz, Nakamba, Drinkwater, Targett, Grealish, Trezeguet, El Ghazi, Hourihane, Jota, Lansbury, Vassilev.
Watford provisional squad: Foster, Cathcart, Hughes, Doucoure, Capoue, Deulofeu, Kabasele, Deeney, Gomes, Dawson, Masina, Foulquier, Chalobah, Pussetto, Pereyra, Quina, Gray, Success.