The Hornets, on the back of a six-match unbeaten streak, will remain outside of the relegation zone if they avoid defeat.
Such has been Watford's recent progression that there would have been disappointment after only recording a goalless draw against Tottenham Hotspur at the weekend.
However, given that it was a contest which either side could have won, Nigel Pearson would have felt a sense of relief that his players were able to extend their excellent run of form.
While an FA Cup replay with Tranmere Rovers on Thursday night complicates matters, Pearson will demand that his players are fully focused on gaining what could eventually turn out to be a pivotal result come the end of the season.
The reverse fixture will also be fresh in the mind of both clubs, with Watford registering a 3-0 triumph with relative ease at Vicarage Road on December 28.
On that occasion, Troy Deeney played an instrumental part, scoring a double and bullying the Villa backline, and the Birmingham-born frontman will be motivated to heap more misery on the rivals of his boyhood club.
From Villa's perspective, they made the headlines for the wrong reasons when they suffered a one-sided 6-1 defeat at the hands of Manchester City last week, who arguably should have won by an even wider margin.
However, at a time when his team are still short of firepower, Dean Smith would have been hugely impressed with his team's spirit in claiming a share of the spoils at Brighton & Hove Albion on Saturday.
Despite the result not being enough to keep Villa out of the relegation zone, they at least ensured that they only remain three points adrift of 14th position, highlighting the competitiveness of the lower regions of the standings.
Jack Grealish took his tally to seven goals and five assists for the season at the Amex Stadium, and Smith may feel that the playmaker needs to produce another inspirational performance on Tuesday night in order to earn a result.
Aston Villa Premier League form: LWLWLD
Aston Villa form (all competitions): LWLDLD
Watford Premier League form: WDWWWD
Watford form (all competitions): DWWDWD
Despite the short recovery period, Smith is unlikely to make many changes to Villa's starting lineup.
However, the rest of the team could stay the same, with Christian Kabasele having to make do with a spot among the replacements.
Aston Villa possible starting lineup:
Reina; Konsa, Mings, Hause; Guilbert, Luiz, Nakamba, Targett; Trezeguet, El Ghazi, Grealish
Watford possible starting lineup:
Foster; Mariappa, Dawson, Cathcart, Masina; Chalobah, Capoue; Pereyra, Doucoure, Deulofeu; Deeney
We say: Aston Villa 1-3 Watford
While Villa are capable of raising their game in front of their own supporters, we cannot back against Watford, who are currently showing everything required to get themselves out of a relegation scrap. As well as their confidence in attack, the Hornets also have the potential to overpower their hosts.