The La Liga side must at least match Bayer Leverkusen's result against already-qualified Juventus, while the Russian outfit are fighting for a third-place finish that would see them drop into the Europa League.
Atletico's recent form leaves something to be desired, however, with no wins in their last four games across all competitions.
Here, Sports Mole looks at how Atletico could line up for Wednesday's showdown.
Jan Oblak is one who will not make way, however, and one of Europe's finest shot-stoppers will be expected to take his usual place between the sticks on Wednesday night.
Ahead of him, impressive young Brazilian Renan Lodi should retain his spot at left-back, while the centre-back partnership of Mario Hermoso and Felipe will continue with Savic and Gimenez struggling with injury.
Koke should continue on the left of the midfield four, but Saul Niguez could be moved back into his preferred central role alongside Thomas Partey, with Angel Correa coming in for Hector Herrera and playing on the right flank to give the team greater impetus in attack.