The visitors make the trip to the Allianz Arena looking to avoid a second successive defeat to Bundesliga opposition after losing to RB Leipzig in last season's quarter-finals.
A consequence of Bayern's run to Champions League glory at the end of the last campaign was a reduced off-season, leaving just a three-and-a-half-week gap between the final and their 2020-21 Bundesliga opener.
Bayern have been far from their best, already suffering a surprise 4-1 defeat at the hands of Hoffenheim, but four successive wins have been recorded in all competitions either side of the international break.
Such was the tight schedule that Bayern had to play twice in 48 hours last week, and a three-day gap ahead of this showdown is certainly not ideal for Flick and his players.
Nevertheless, there will equally be a desire to find some consistency, particularly in defence after conceding 11 goals across their last half-a-dozen matches.
At the other end of the pitch, Robert Lewandowski has been in phenomenal form, already contributing seven goals and three assists from just 299 minutes of football.
While Atletico have had a much less hectic start to the season, Diego Simeone has witnessed his side already drop points to Huesca and Villarreal respectively.
Given the inconsistencies of every team in La Liga, Atletico will go top of the table if they win their games in hand, but their boss will naturally want to see improvements in the final third.
Luis Suarez is still settling into life at Wanda Metropolitano, although the Uruguayan star has already chipped in with three goals and an assist from four appearances.
Providing that he eventually receives assistance from Atletico's other flair players, last season's quarter-finalists look in good shape to challenge for silverware this season.
Los Rojiblancos have gone 273 minutes without conceding a goal ahead of squaring off against European football's most ruthless attack.
Bayern Munich form (all competitions): WLWWWW
Atletico Madrid form (all competitions): WDDW
Simeone will likely hand another start to Lucas Torreira, who impressed on his Atletico debut against Celta Vigo.
Flick is unlikely to tinker with his current Bayern XI, meaning that Alphonso Davies could be named on the substitutes' bench.
Bayern Munich possible starting lineup:
Neuer; Pavard, Sule, Alaba, Hernandez; Tolisso, Goretzka; Costa, Muller, Coman; Lewandowski
Atletico Madrid possible starting lineup:
Oblak; Trippier, Savic, Felipe, Lodi; Llorente, Torreira, Koke, Carrasco; Suarez, Felix
We say: Bayern Munich 3-1 Atletico Madrid
While neither team have produced their best form during a hectic start to the season, we cannot look past the home side. Flick and his players will be motivated to retain their trophy this season, and that desire could lead to a statement performance being produced on Wednesday evening.