Atletico Madrid will be looking to atone for elimination from the Europa League when they take on Espanyol at the Vicente Calderon.
Los Colchoneros' defence of the trophy ended against Rubin Kazan, despite them winning 1-0 in Russia.
Diego Simeone's men are second in the table, but have seen their lead over city rivals Real Madrid cut to four points.
Meanwhile, 12th-placed Espanyol currently top the form table in Spain having taken 16 points from the last 18 available.
Last week's 1-0 win over Real Betis was their third in a row.
Recent form Atletico:
Espanyol: WWDWWW
Possible lineups Atletico:
Espanyol: Casilla; Colotto, Moreno, Capdevilla, Forlin; Simao, Verdu, Sanchez, Lopez; Garcia, Stuani
Sports Mole says: 1-0