Antoine Griezmann returns to the starting XI as Atletico Madrid welcome Malaga in the first game at their new stadium this evening.
An all-day party has been taking place at the new, 68,000-seater Wanda Metropolitano ahead of the fixture, which sees the French striker back in the fold after a two-game ban.
Luciano Vietto drops down to the bench as Griezmann partners up with Angel Correa following successive goalless draws - in the league at Valencia and in the Champions League at Roma.
Gabi replaced Yannick Carrasco in the Italian capital and keeps his place in the midfield tonight alongside Saul Niguez, Teye Thomas and Koke.
Stefan Savic is left on the bench as Diego Godin and Lucas Hernandez get the nod to start in the centre of defence, with Juanfran at right-back, Filipe Luis on the left and Jan Oblak between the posts.
Fernando Torres is among Simeone's other options on the bench.
Malaga manager Michel, meanwhile, makes just two changes following the 3-1 defeat to Las Palmas on Monday, bringing in Chory Castro and Esteban Rolan for Jose Mauri and Zdravko Kuzmanovic in the midfield.
Borja once again leads the line in a 4-5-1 formation, with Castro and Rolon joining Recio - passed fit despite hamstring worries - Adrian Gonzalez and Alejandro Mula.
Roberto remains in place between the sticks behind a back four of Roberto Rosales, Luis Hernandez, Diego Gonzalez and Federico Ricca.
Atletico Madrid: Oblak; Juanfran, Godin, Hernandez, Filipe Luis; Niguez, Thomas, Gabi, Koke; Correa, Griezmann
Subs: Moya, Savic, Carrasco, Gaitan, Torres, Vietto, Gameiro
Malaga: Roberto; Rosales, Luis Hernandez, Diego Gonzalez, Ricca; Rolon, Recio, Mula, Chory, Adrian; Borja
Subs: Andres Prieto, Kuzmanovic, Juanpi, Cifuentes, Keko Gontan, Baysse, D. Rolan