Luis Enrique has made two changes to the Barcelona side which lost at Sevilla two weeks ago.
Dani Alves comes into the starting lineup to replace Javier Mascherano, who drops to the bench, while 20-year-old forward Sandro comes in for Munir.
Meanwhile, Rayo Vallecano have made two changes to the team which lost to Real Betis a fortnight ago.
Lass Bangoura and Patrick Ebert come in for Raul Baena and Adri Embarda in midfield.
Barcelona: Bravo; Sergi Roberto, Piqué, Mathieu, Alba; Alves, Busquets, Rakitic; Sandro, Suárez, Neymar
Subs: Ter Stegan, Douglas, Mascherano, Barta, Adriano, Gumbau, Munir
Rayo Vallecano: Tono; Nacho, Llorente, Ze Castro, Rat; Jozabed, Trashorras, Bangoura; Bebe, Ebert, Guerra
