Lionel Messi, Luis Suarez and Neymar will all start for Barcelona, as new Valencia head coach Gary Neville will watch his side from the stands.
It is only the second start Messi will make since returning from injury, with Jordi Alba also returning to the starting XI in place of Jeremy Mathieu.
Valencia assistant coach Phil Neville makes five changes to the side that beat Barakaldo 3-1 in the Copa del Rey in midweek, as Aymen Abdennour regains his place in the heart of the defence.
Paco Alcacer and Rodrigo de Paul also return to spearhead the home side's attack, alongside Santi Mina.
Valencia: Domenech; Ruben Vezo, Santos, Abdennour, Gaya; Danilo, Parejo, Perez; Mina, De Paul, Alcacer
Subs: Pareja, Piatti, Bakkali, Ryan, Carbonell Gil, Villalba, Diallo
Barcelona: Bravo; Alba, Pique, Mascherano, Alves; Rakitic, Busquets, Iniesta, Messi, Neymar, Suarez
Subs: Ter Stegen, Bartra, Munir, Sandro, Adriano, Vermaelen, Samper
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