The home side are in real trouble, level on points with bottom club Luton Town, while Huddersfield are sitting gingerly in 20th place.
Having achieved promotion to the second tier last season, Barnsley look painfully out of place in the Championship so far this term.
They have the fewest victories for any Championship side at this stage of the season (four) and possess the second-worst defensive record, shipping 49 goals in 26 outings.
The appointment of Gerhard Struber as manager in November was designed to invoke an uptick in results, but aside from back-to-back victories over Queens Park Rangers and Millwall, there has been little to smile about at Oakwell.
Despite only being three points from safety, there is a strong feeling that this Barnsley side simply does not have the resources necessary for successfully navigating a Championship season.
The meeting with Huddersfield, who are in similar form, will at least give Struber's men a decent chance of gaining some confidence in the final third.
If Barnsley are an example of a team struggling after promotion to the Championship, Huddersfield can be seen as a club failing to cope with suffering relegation to the division last season.
Following a dismal second Premier League campaign, during which David Wagner left his post, the club has failed to reinvent itself in the more familiar surroundings of the second tier.
Indeed, given that so many key players - Aaron Mooy, Jonas Lossl, Laurent Depoitre, Rajiv van La Parra, Erik Durm and Philip Billing - left over the summer, it is perhaps not surprising to see something of an identity crisis occurring at the Yorkshire side.
Manager Danny Cowley, appointed as manager in September, has seen his side show moments of promise - he went unbeaten in his first eight games - but a recent 5-2 home defeat to Stoke City demonstrated how this team continues to lack a solid foundation on which to build momentum.
A win over Barnsley, who are in an even worse position, would nonetheless provide Huddersfield with more daylight between themselves and the bottom three as they enter the business end of the campaign.
Barnsley Championship form: WWDDLW
Barnsley form (all competitions): DWWDDL
Huddersfield Town Championship form: WDWLWL
Huddersfield form (all competitions): DWLWLL
Barnsley have the blessing of no injuries ahead of this game, meaning that Struber can name a full-strength starting XI.
Conor Chaplin, who has eight Championship goals this term and scored against Crewe Alexandra over the weekend, is expected to lead the line once again.
Defender Tommy Elphick is out for the entire season after picking up a severe knee injury in November.
Barnsley possible starting lineup:
Radlinger; Williams, Diaby, Andersen, Oduor; Halme, Mowatt, Bahre; Thomas, Schmidt, Chaplin
Huddersfield Town possible starting lineup:
Grabara; Simpson, Schindler, Stankovic, Brown; Chalobah, Hogg, O'Brien, Bacuna; Ahearne-Grant, Mounie
We say: Barnsley 1-2 Huddersfield Town
Barnsley will throw everything at this game, getting the ball into the final third as often as possible, but their woeful defensive record means that the home side are very likely to ship goals at the other end.