The Manchester City playmaker is recovering from two facial fractures sustained in the Champions League final, and manager Roberto Martinez does not expect him to feature in the tournament's opener with Russia on June 12.
De Bruyne is not alone in the Red Devils' infirmary, though, as Axel Witsel is not quite ready to return from his Achilles issue just yet, although the Borussia Dortmund man is making good progress on the training pitches.
Martinez should shuffle the pack for Sunday's game given the quick turnaround in fixtures, starting with Thibaut Courtois possibly coming back in for Simon Mignolet in goal as Jan Vertonghen takes his rightful place in defence ahead of Dedryck Boyata.
Thomas Meunier played the full 90 minutes in their 1-1 draw with Greece and could make way for Leicester City's Timothy Castagne, and the defender's fellow Fox Youri Tielemans may replace another King Power teammate in Dennis Praet in midfield.
Belgium possible starting lineup: Courtois; Alderweireld, Denayer, Vertonghen; Castagne, Tielemans, Dendoncker, T. Hazard; Doku, Lukaku, Trossard body check tags ::