RB Leipzig vs. Hertha Berlin (Saturday, 2.30pm)
Last year's runners-up have managed just one win so far, whilst the visitors have come alive after back-to-back wins since returning from the international break.
We say: RB Leipzig 2-1 Hertha Berlin
Home advantage may prove important for this struggling Leipzig side at the weekend. They are far from their best at the moment but they should have enough quality to see off Hertha, with us predicting a narrow victory for the hosts.
Frankfurt vs. FC Koln (Saturday, 2.30pm)
The visitors have enjoyed a promising start to their campaign and they head into the weekend in seventh position having amassed eight points so far this term.
We say: Eintracht Frankfurt 2-1 FC Koln
Despite being winless this season, Frankfurt can take confidence from the fact they are unbeaten in their last five matches in all competitions.
Though Koln have been in fine form, they are yet to win away this term, and as a result we think Frankfurt will edge this encounter to get their first three points of the campaign.
B. Leverkusen vs. Mainz 05 (Saturday, 2.30pm)
The hosts find themselves in a Champions League position under their new manager, with the visitors sitting just one place behind them as they unexpectedly continue their strong form from last campaign.
We say: Bayer Leverkusen 2-1 Mainz 05
Leverkusen will be hoping their clinical finishing can come to their assistance against a stubborn and well-drilled Mainz side on Saturday. It could be a tight affair but the hosts should possess enough quality to see off the visitors eventually, particularly with the likes of Diaby, Wirtz and Schick at their disposal.
Union Berlin vs. Arminia Bielefeld (Saturday, 2.30pm)
The hosts sit in eighth place on six points, while their opponents have only collected four points this season and are still searching for their first win of the campaign.
We say: Union Berlin 2-1 Arminia Bielefeld
Union Berlin are balancing domestic football with a European campaign, and they may have one eye on their home game against Maccabi Haifa next week, but they should have enough quality to see off an Arminia Bielefeld side who are struggling to score.
Hoffenheim vs. Wolfsburg (Saturday, 2.30pm)
Meanwhile, the hosts find themselves in mid-table after failing to win since the opening weekend of league action.
We say: Hoffenheim 1-1 Wolfsburg
With Hoffenheim's last couple of matches being tight affairs, and all of Wolfsburg's being that case this season so far, another is expected here. Neither look like they have the ability to score a number of goals just yet so a low-scoring draw is our prediction here.
Borussia M'bach vs. Dortmund (Saturday, 5.30pm)
Although not a regional derby, this match still has that little bit extra at stake when the two sides meet, and entertaining encounters usually follow.
We say: Borussia Monchengladbach 1-3 Borussia Dortmund
On paper it appears as though this should be a highly entertaining and open game of football. With Dortmund's woeful defending so far this season, they are sure to concede one or two goals again against a strong opponent, but the devastating form of Haaland and co in the forward line should see them over the line once more.