Gladbach suffered a 3-1 defeat at home to Bayer Leverkusen on Saturday to drop out of the top four, while Bremen occupy 17th position in the table despite picking up an important win against Freiburg last time out.
Bremen have not operated outside of the Bundesliga since the 1980-81 campaign, but it would be fair to say that the team are very much in a relegation battle during the 2019-20 season.
A total of 21 points from 26 matches has left them in 17th position, three points behind 16th-placed Fortuna Dusseldorf, who threw away a two-goal lead to draw 2-2 with Koln in Sunday's late start.
Bremen are six points from the safety of 15th position, although they have a game in hand on every team in the division other than Eintracht Frankfurt, who are also in the relegation mix at this stage.
Florian Kohfeldt's side will enter Tuesday's match off the back of an impressive victory at Freiburg, though, and they beat Borussia Dortmund on home soil in the German Cup in February.
Gladbach would have been looking to cement their spot in the top four when they welcomed Leverkusen on Saturday afternoon, but the visitors - inspired by the excellent Kai Havertz - recorded an impressive 3-1 victory.
Marco Rose's side beat Frankfurt 3-1 on their return to Bundesliga action last weekend, though, and have been victorious in three of their last five in Germany's top flight to leave themselves in a decent spot.
Indeed, Gladbach are currently fifth in the table, just one point off fourth-placed Leverkusen and two behind third-placed RB Leipzig, who put five unanswered goals past Mainz 05 on Sunday.
Rose's team are actually only five points off Dortmund in second, meanwhile, and only the top two sides have picked up more league victories than the four-time Bundesliga champions this season.
Die Fohlen are also unbeaten in their last eight Bundesliga meetings with Bremen and recorded a 3-1 victory when the pair met in the reverse match back in November.
Werder Bremen Bundesliga form: LLLDLW
Werder Bremen form (all competitions): LLLDLW
Gladbach Bundesliga form: DWLWWL
Davy Klaassen returned from suspension against Freiburg at the weekend, and the Dutchman's impressive performance should see him keep his spot in the middle of the Bremen midfield.
There will once again be eyes on Milot Rashica, who has scored 10 times and registered five assists in 26 appearances this season. Liverpool are thought to be keen on the Kosovo international, who is expected to line up on the left of a front three.
Philipp Bargfrede is also suspended after being sent off late on against Freiburg.
Rose is expected to resist the temptation to make wholesale changes for Tuesday's affair, although Laszlo Benes is pushing for a spot in the middle of midfield.
Bremen possible starting lineup:
Pavlenka; Gebre Selassie, Veljkovic, Moisander, Freidl; Eggestein, Vogt, Klaassen; Bittencourt, Sargent, Rashica
Gladbach possible starting lineup:
Sommer; Lainer, Ginter, Elvedi, Bensebaini; Neuhaus, Benes; Thuram, Stindl, Hofmann; Plea
We say: Werder Bremen 1-2 Borussia Monchengladbach
Bremen picked up an impressive victory against Freiburg, but there is no getting away from the fact that they have lost 15 of their 26 league games this term. Gladbach will be determined to return to winning ways, and we expect the visitors to pick up an important three points at Weserstadion.
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