Bournemouth failed to assert their dominance against the Lions as Dominic Solanke's opener in first-half stoppage time was cancelled out by Matt Smith at the Vitality Stadium.
The Cherries are the division's joint-highest scorers with 38 goals but have not netted more than once in a league game since their 5-0 demolition of Huddersfield Town on December 12.
This will be Bournemouth's third home game in the space of a week after beating Oldham Athletic 4-1 in the FA Cup on the south coast last Saturday, and they have a strong record at the Vitality Stadium this season, losing just once.
It is a first league visit to Boscombe since 2009 for Luton, when the two clubs were in the bottom half of League Two; they have had contrasting fortunes since then, with the Hatters playing five seasons of non-league football and the Cherries spending the same amount of time in the top-flight.
Indeed, it is easy to forget that Luton were in League Two only three years ago as they now sit comfortably in mid-table in the Championship primarily thanks to the work of Nathan Jones. The Bedfordshire outfit are currently 14th – 11 points clear of relegation danger and seven points behind the playoff places.
Yet to climb even higher they must improve their consistency as a defeat to a struggling QPR team in midweek followed a win over playoff chasing Bristol City and progress in the FA Cup against a youthful Reading side.
Luton have only scored five goals away from home in the Championship season – the lowest in the division – and have failed to win their last six games on the road. It does not get any easier after this weekend either as the Hatters travel to high-flying Brentford and then Chelsea in the FA Cup.
Bournemouth Championship form: WWDLWD
Bournemouth form (all competitions): WDLWWD
Luton Town Championship form: WLDLWL
Luton Town form (all competitions): LDLWWL
Junior Stanislas is a doubt for Saturday's game after being forced off in the second half against Millwall with an ankle injury before leaving the ground on crutches wearing a protective boot.
Full-back Jack Stacey returned from a seven-week long injury against Oldham in the FA Cup before dropping to the bench in midweek but could come back into the side.
Jones may also look to recruit upfront, as James Collins has not scored since his hat-trick against Preston five weeks ago, while no other forward has more than one goal this season.
Bournemouth possible starting lineup:
Begovic; Cook, Simpson, Kelly; Stacey, Lerma, Cook, Smith; Brooks, Solanke, King
Luton Town possible starting lineup:
Sluga; Bree, Lockyer, Bradley, Potts; Rea; Cornick, Dewsbury-Hall, Mpanzu, LuaLua; Collins
We say: Bournemouth 2-0 Luton Town
Both managers were disappointed with their sides' performances in midweek so will be demanding a response on Saturday; that could make for an exciting encounter, but Bournemouth's quality should shine through.