Brighton come into this match off the back of a poor run of form, having picked up just five points from their last six Premier League matches.
A 1-0 defeat last time out against Everton at Goodison Park was the latest match in a difficult run for the Seagulls, during which they faced Tottenham Hotspur, Sheffield United and Chelsea.
However, Brighton's home form has been a strong point this season, with the South coast side picking up four wins and four draws at the Amex.
A win could see Potter's side climb as high as 13th, but a defeat could see them fall into the drop zone.
Villa too come into this match off the back of a loss after they were beaten 6-1 at home by Manchester City.
It was a chastening result for Dean Smith's side, who had won two of their past three matches before the visit of the champions.
A key issue for the Villans this season has been their form on the road, picking up just seven points away from Villa Park in the league.
The Midlands side have already beaten Brighton twice this season though, winning 3-1 at the Amex in the EFL Cup and securing a 2-1 win in the Premier League reverse fixture.
Brighton competition form: DLLWDL
Brighton form (all competitions): LLWDLL
Aston Villa competition form: LLWLWL
Aston Villa form (all competitions): WLWLDL
Finally, new signing Pepe Reina should make his debut after securing his loan move from AC Milan.
Brighton possible starting lineup:
Ryan; Webster, Duffy, Dunk; Montoya, Stephens, Propper, Bernardo; Mooy, Maupay, Trossard
Aston Villa possible starting lineup:
Reina; Elmohamady, Mings, Ngoyo, Taylor; Nakamba, Drinkwater, Hourihane; Grealish, El Ghazi, Trezeguet
We say: Brighton 1-1 Aston Villa
Both sides come into this fixture low on confidence and with injuries blighting their squads. As a result, expect a close, cagey affair, with neither side quite able to create enough chances to force a winner.