Celtic stormed to the title with relative ease once again last season, whereas Hamilton just managed to stave off relegation when the campaign was curtailed.
Bayern Munich have now been crowned Bundesliga champions eight times in a row, Juventus recently clinched their ninth Serie A title on the bounce, and now it is Celtic's turn to try to secure an unprecedented 10th straight triumph in the Scottish top division.
Neil Lennon's side finished last season a whopping 13 points ahead of fierce rivals Rangers, albeit having played a game more, and Celtic will no doubt feel confident about their chances of finishing atop the rankings once again this time around.
Lennon's men travelled to France for the first half of their pre-season, but Celtic's time abroad was nothing to write home about as they drew with Nice before suffering defeats to Lyon and Paris Saint-Germain, with former Bhoys striker Moussa Dembele netting for Lyon against his old club.
Upon their return to familiar surroundings, Celtic rounded off their pre-season with comfortable victories over Ross County and Hibernian as the Bhoys look to make history in the 2020-21 Scottish Premiership campaign.
Celtic won nine of their 10 league games in 2020 before the season was abruptly ended, and Lennon's side have tasted victory in 31 of their last 34 Scottish Premiership games at Celtic Park, with their solitary home defeat last season coming against Rangers back in December.
In contrast, Hamilton finished four points clear of relegated Hearts and can now look forward to a seventh consecutive season of Scottish Premiership football.
The Accies managed to string together a four-game unbeaten run just before the season was curtailed, including a historic 1-0 win at Rangers in the penultimate game of the campaign before victory by the same scoreline against Kilmarnock ensured their survival.
Brian Rice will no doubt want to see his players carry that momentum forward into the opening weekend, but Celtic have won the last 12 meetings between the two sides and have only lost to Hamilton once in 27 matches.
Avoiding relegation will be the bare minimum for Hamilton once again this time around, but Rice's men will be facing an uphill struggle this weekend against a Celtic side looking to etch their name in the history books.
New arrival Vasilis Barkas is expected to be handed his debut in goal for Celtic, with the 26-year-old having just made the switch to Scotland from Greek outfit AEK Athens.
Lennon opted for a 3-5-2 system for the second half of last season but may revert back to a 4-2-3-1 here, which would most likely see Odsonne Edouard lead the line despite speculation linking him with a move elsewhere, although fellow striker Leigh Griffiths has notched up nine goals in this fixture.
As for Hamilton, captain Brian Easton is recovering from ankle surgery and will not be back out on the pitch for at least another few weeks.
Celtic possible starting lineup:
Barkas; Frimpong, Jullien, Ajer, Taylor; Brown, McGregor; Forrest, Christie, Elyounoussi; Edouard
Hamilton possible starting lineup:
Williams; McKenna, Fjortoft, Hamilton, McMann; Hughes, Smith, Martin, Cunningham; Moyo, Ogboe
We say: Celtic 4-0 Hamilton
Both of these clubs finished the 2019-20 campaign strongly and will be in desperate need of fast starts for entirely different reasons here. However, Celtic are enjoying a period of unparalleled dominance in the Scottish football scene and we cannot see any other result than a straightforward victory for the champions this weekend.