The Bavarian giants lead 3-0 from February's first leg and enter this return fixture on a 17-game winning streak in all competitions.
Having already sealed the Bundesliga title and DFB-Pokal, Hansi Flick will now be looking to make it three trophies out of three in his first half-season in charge.
Here, Sports Mole looks at how Bayern could line up against Chelsea - the side that defeated them on home soil in the 2012 final - in Saturday's clash.
Flick has indicated that he will field a strong starting lineup this weekend, giving his players a chance to rebuild fitness after a month off.
Robert Lewandowski took his goals tally to 53 for the season with his brace in the DFB-Pokal win over Bayer Leverkusen and will lead the line.
The Polish striker has scored 11 goals and assisted two more in six Champions League appearances this season, averaging a goal or assist every 41 minutes.
Another nailed-on starter is Serge Gnabry, who scored twice in the first leg and also netted the winner in last week's friendly victory over Marseille.