The summer signing missed the shock 2-1 defeat at Crystal Palace over the weekend due to a hamstring injury but is passed fit enough to start from the off as the Blues look to extend their 100% record in Group C.
Morata is expected to play up front alongside Eden Hazard in a 3-1-4-2 formation, with Davide Zappacosta coming in for Moses on the right wing alongside Cesc Fabregas, Tiemoue Bakayoko and Marcos Alonso.
For the visitors, Eusebio Di Francesco makes five alterations from the side that started the 1-0 loss to Napoli at the weekend, switching to an expected 4-3-3 formation.
Gerson joins up with Edin Dzeko and Diego Perotti in the attacking line, with Lorenzo Pellegrini, Daniele De Rossi and Alessandro Florenzi all dropping down to the bench as Kevin Strootman and Maxime Gonalons join reported Blues target Radja Nainggolan in the midfield.
One change in the back four sees Kostas Manolas - out with an adductor injury - replaced by Federico Fazio as centre-back partner for Juan Jesus, with Bruno Peres on the right, Aleksandar Kolarov on the left and Alisson Becker in goal.
Chelsea: Courtois; Azpilicueta, Christensen, Cahill; David Luiz; Zappacosta, Fabregas, Bakayoko, Alonso; Hazard, Morata
Subs: Caballero, Rudiger, Scott, Kenedy, Pedro, Willian, Batshuayi
Roma: Becker; Peres, Fazio, Jesus, Kolarov; Nainggolan, Gonalons, Strootman; Gerson, Dzeko, Perotti
Subs: Skoruposki, Pellegrini, Moreno, De Rossi, Under, Florenzi, El Shaarawy
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