The Brazilian midfielder was taken off with a suspected hamstring problem in the midweek win over Aston Villa and is unlikely to return before the Champions League final.
With plenty of key fixtures still to come this season, Klopp will avoid taking any unnecessary risks over Fabinho, but Roberto Firmino was fit enough to make the bench at Villa Park.
Despite his EFL Cup exploits against Chelsea, Caoimhin Kelleher will take his place on the bench as Alisson Becker takes control of the gloves, with Trent Alexander-Arnold and a well-rested Andy Robertson bombing down the flanks.
Joel Matip was on hand to convert at Villa Park but will likely make way for knockout specialist Ibrahima Konate, while Fabinho's expected absence should see Jordan Henderson play in the holding role.
Liverpool possible starting lineup: Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Keita, Henderson, Thiago; Salah, Mane, Diaz
> Click here to see how Chelsea could line up for the final body check tags ::