Kante had initially been tipped to miss a week after sustaining a knee injury against Juventus on November 23, but the Frenchman will now be absent for a third game in succession.
Speaking to reporters at his pre-match press conference, Tuchel also acknowledged that Trevoh Chalobah had joined Mateo Kovacic and Ben Chilwell on the sidelines after being withdrawn with a hamstring problem against Watford.
The German said: "It is a lot of midfield players. It has been many weeks for Kova, we miss him, and NG.
"Ben Chilwell is a long one, and for Trevoh, we need more examinations to see how bad the injury is."
Tuchel also revealed that Reece James would return to the squad after missing the trip to Vicarage Road. body check tags ::