The Blues' Euro 2020 final quintet - Jorginho, Emerson, Mason Mount, Ben Chilwell and Reece James - are all due to report back for training this week, but this friendly will come too soon for any of them to be involved.
Edouard Mendy started in his side's 2-1 victory over Arsenal at the weekend, but Kepa Arrizabalaga could be given the nod from the first whistle here as Malang Sarr joins Kurt Zouma and Antonio Rudiger in the back three.
Two changes in the engine room could see Ross Barkley and N'Golo Kante earn starts as Mateo Kovacic and Ruben Loftus-Cheek - who has been told by Tuchel that he is free to decide his own Chelsea future - prepare for substitute cameos.
Hakim Ziyech somehow failed to double his side's lead on Sunday at the Emirates with the goal gaping but could be handed another opportunity on the right-hand side here, in spite of persistent links with AC Milan.
Tammy Abraham - also being strongly linked with a move elsewhere - netted the winner against Arsenal and will hope to step foot onto the Stamford Bridge turf here, although Michy Batshuayi is another fringe player pushing for action in blue.
Chelsea possible starting lineup: Kepa; Zouma, Sarr, Rudiger; Hudson-Odoi, Kante, Barkley, Pulisic; Ziyech, Werner; Abraham