As a result of suffering a 3-1 defeat at the hands of Liverpool before the international break, City now sit in fourth position, one point adrift of the Blues.
However, Pep Guardiola's side head into this contest having won five of the last six encounters between the two clubs.
Here, Sports Mole predicts how the defending champions could line up for the showdown at the Etihad Stadium.
City will be without midfielder Bernardo Silva after the Portuguese was handed a one-match ban for a post made on social media.
However, goalkeeper Ederson has provided Guardiola with a much-needed boost after returning to training after a muscle injury - a development which should see the Brazilian stopper replace Claudio Bravo.
With Bernardo sitting out the game and Leroy Sane still a couple of months away from recovering from a knee injury, Riyad Mahrez may feature on the right flank.