Depor were back in the match 20 minutes from time through Riera, but Sevilla scored a fourth through a Sidnei own goal late on to move 4-2 ahead.
Lucas Perez netted a penalty for Depor in the fourth minute of stoppage time, but it proved no more than a consolation as Sevilla recorded all the points.
Read how it all unfolded in Sports Mole's minute-by-minute live commentary of the action below.
DEPOR: Fabricio; Juanfran, Insua, Sidnei, Luisinho; Bergantinos, Borges; Cuenca, Lucas, Cavaleiro; Riera
SEVILLA: Rico; Diogo, Pareja, Kolo, Navarro; Iborra, Krychowiak; Vidal, Banega, Vitolo; Bacca